“NAVAN recommends that the most appropriate location for the tip of peripherally inserted central catheters (PICCs) is the lower one-third of the superior vena cava (SVC), close to the junction of the SVC and the right atrium. This tip location allows the catheter to float freely within the vein lumen and lie parallel to the vessel wall, resulting in a considerable reduction in such complications as thrombosis and infection.” (JVAD 1998)
JVAD (1998) Tip location of Peripherally Inserted Central Catheters. JVAD. Summer 1998.